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Oral lichen planus

MedGen UID:
60084
Concept ID:
C0206139
Disease or Syndrome
Synonym: Oral lichenoid lesions
SNOMED CT: OLP - Oral lichen planus (235049008); Oral lichen planus (235049008)
 
Monarch Initiative: MONDO:0043923

Definition

A chronic, autoimmune inflammatory condition of the mucous membranes in the oral cavity that affects approximately two percent of the population and is most often seen in middle aged women. It is characterized by white, lacy patches; red, swollen tissue; papules and plaques; or open sores. The lesions are typically bilateral. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral lichen planus

Professional guidelines

PubMed

Louisy A, Humbert E, Samimi M
Am J Clin Dermatol 2024 Jan;25(1):35-53. Epub 2023 Sep 15 doi: 10.1007/s40257-023-00814-3. PMID: 37713153
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A
J Formos Med Assoc 2018 Sep;117(9):756-765. Epub 2018 Feb 19 doi: 10.1016/j.jfma.2018.01.021. PMID: 29472048
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997

Recent clinical studies

Etiology

Liao H, Luo Y, Long L, Peng J, Qiu X, Yuan P, Xu H, Jiang L
Oral Dis 2021 Apr;27(3):506-514. Epub 2020 Aug 11 doi: 10.1111/odi.13569. PMID: 32697012
Carrozzo M, Porter S, Mercadante V, Fedele S
Periodontol 2000 2019 Jun;80(1):105-125. doi: 10.1111/prd.12260. PMID: 31090143
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article
Ion DI, Setterfield JF
Prim Dent J 2016 Feb 1;5(1):40-44. doi: 10.1177/205016841600500104. PMID: 29029652
Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S
Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Sep;122(3):332-54. Epub 2016 Jul 9 doi: 10.1016/j.oooo.2016.05.004. PMID: 27401683

Diagnosis

Louisy A, Humbert E, Samimi M
Am J Clin Dermatol 2024 Jan;25(1):35-53. Epub 2023 Sep 15 doi: 10.1007/s40257-023-00814-3. PMID: 37713153
Hamour AF, Klieb H, Eskander A
CMAJ 2020 Aug 4;192(31):E892. doi: 10.1503/cmaj.200309. PMID: 32753462Free PMC Article
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A
J Formos Med Assoc 2018 Sep;117(9):756-765. Epub 2018 Feb 19 doi: 10.1016/j.jfma.2018.01.021. PMID: 29472048
Alrashdan MS, Cirillo N, McCullough M
Arch Dermatol Res 2016 Oct;308(8):539-51. Epub 2016 Jun 27 doi: 10.1007/s00403-016-1667-2. PMID: 27349424

Therapy

Louisy A, Humbert E, Samimi M
Am J Clin Dermatol 2024 Jan;25(1):35-53. Epub 2023 Sep 15 doi: 10.1007/s40257-023-00814-3. PMID: 37713153
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721
Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, Axéll T, Bruce AJ, Carpenter W, Eisenberg E, Epstein JB, Holmstrup P, Jontell M, Lozada-Nur F, Nair R, Silverman B, Thongprasom K, Thornhill M, Warnakulasuriya S, van der Waal I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Mar;103 Suppl:S25.e1-12. Epub 2007 Jan 29 doi: 10.1016/j.tripleo.2006.11.001. PMID: 17261375

Prognosis

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, Stefanato CM, Fenton DA, McGrath JA
J Am Acad Dermatol 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010. PMID: 30318136
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799

Clinical prediction guides

Xie Y, Xu H, Li C, Wang Y, Lu R, Hua H, Tang G, Zhou G, Jin X, Shang Q, Dan P, Zhang C, Luo X, Dan H, Zeng X, Zhou Y, Chen Q
Oral Dis 2024 Jul;30(5):3126-3135. Epub 2023 Oct 4 doi: 10.1111/odi.14746. PMID: 37794749
Li Q, Wang F, Shi Y, Zhong L, Duan S, Kuang W, Liu N, Luo E, Zhou Y, Jiang L, Dan H, Luo X, Zhang D, Chen Q, Zeng X, Li T
Front Immunol 2023;14:1182732. Epub 2023 Apr 6 doi: 10.3389/fimmu.2023.1182732. PMID: 37090715Free PMC Article
Mallah N, Ignacio Varela-Centelles P, Seoane-Romero J, Takkouche B
Oral Dis 2022 Nov;28(8):2100-2109. Epub 2021 Jun 11 doi: 10.1111/odi.13927. PMID: 34051029
Liao H, Luo Y, Long L, Peng J, Qiu X, Yuan P, Xu H, Jiang L
Oral Dis 2021 Apr;27(3):506-514. Epub 2020 Aug 11 doi: 10.1111/odi.13569. PMID: 32697012
Nosratzehi T
Asian Pac J Cancer Prev 2018 May 26;19(5):1161-1167. doi: 10.22034/APJCP.2018.19.5.1161. PMID: 29801395Free PMC Article

Recent systematic reviews

Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:896476. Epub 2022 Aug 1 doi: 10.3389/fimmu.2022.896476. PMID: 35979355Free PMC Article
González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, Ruiz-Ávila I, Ramos-García P
Oral Dis 2021 May;27(4):813-828. Epub 2020 Apr 2 doi: 10.1111/odi.13323. PMID: 32144836
García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Med Clin (Barc) 2017 Oct 23;149(8):351-362. Epub 2017 Jul 28 doi: 10.1016/j.medcli.2017.06.024. PMID: 28756997
Vaughn AR, Branum A, Sivamani RK
Phytother Res 2016 Aug;30(8):1243-64. Epub 2016 May 23 doi: 10.1002/ptr.5640. PMID: 27213821
Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, Axéll T, Bruce AJ, Carpenter W, Eisenberg E, Epstein JB, Holmstrup P, Jontell M, Lozada-Nur F, Nair R, Silverman B, Thongprasom K, Thornhill M, Warnakulasuriya S, van der Waal I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Mar;103 Suppl:S25.e1-12. Epub 2007 Jan 29 doi: 10.1016/j.tripleo.2006.11.001. PMID: 17261375

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